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Article

Loss of the Inactive X Chromosome and Replication of the Active X in BRCA1-Defective and Wild-type Breast Cancer Cells

15 Mar 2005

Abstract excerpt

In females, X chromosome inactivation (XCI) begins with the expression of the XIST gene from the X chromosome destined to be inactivated (Xi) and the coating of XIST RNA in cis. It has recently been reported that this process is supported by the product of the BRCA1 tumor suppressor gene and that BRCA1-/- cancers show Xi chromatin structure defects, thus suggesting a role of XCI perturbation in BRCA1-mediated...

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PMID: 15781624
DOI: 10.1158/0008-5472.can-04-3465

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Related research

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Research trail→

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Loss of the Inactive X Chromosome and Replication of the Active X in BRCA1-Defective and Wild-type Breast Cancer CellsPMID 15781624Read ↗

Misbehaviour of XIST RNA in breast cancer cells.Semantic proximity Read ↗

Expression and Function of a Large Non‐coding RNA Gene XIST in Human CancerSemantic proximity Read ↗

A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation.Semantic proximity Read ↗

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Polymorphic X-chromosome inactivation of the human TIMP1 gene.Semantic proximity Read ↗

Xist is expressed in female embryonal carcinoma cells with two active X chromosomes.Semantic proximity Read ↗

Mosaic methylation of Xist gene before chromosome inactivation in undifferentiated female mouse embryonic stem and embryonic germ cells.Semantic proximity Read ↗

X chromosome inactivation pattern in BRCA gene mutation carriers.Semantic proximity Read ↗

Chromatin structure analysis of the mouse Xist locus.Semantic proximity Read ↗

Association Between Nonrandom X-Chromosome Inactivation and BRCA1 Mutation in Germline DNA of Patients With Ovarian CancerSemantic proximity Read ↗

Frequent loss Xq25 on the inactive X chromosome in primary breast carcinomas is associated with tumor grade and axillary lymph node metastasis.Semantic proximity Read ↗

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