Article
Molecular and cytogenetic analysis of the spreading of X inactivation in X;autosome translocations.
Human molecular genetics - 1 Dec 2002
Sharp Andrew J, Spotswood Hugh T, Robinson David O, Turner Bryan M, Jacobs Patricia A
Abstract excerpt
We have performed detailed studies of the spreading of X inactivation in five unbalanced human X;autosome translocations. Using allele-specific RT-PCR we observed long-range silencing of autosomal genes located up to 45 Mb from the translocation breakpoint, directly demonstrating the ability of X inactivation to spread in cis through autosomal DNA. Spreading of gene silencing occurred in either a continuous or...
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