Article
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.
Molecular and cellular biology - 1 Aug 1997
Diaz B, Barnard D, Filson A, MacDonald S, King A, Marshall M
Abstract excerpt
Activation of the Raf serine/threonine protein kinases is tightly regulated by multiple phosphorylation events. Phosphorylation of either tyrosine 340 or 341 in the catalytic domain of Raf-1 has been previously shown to induce the ability of the protein kinase to phosphorylate MEK. By using a com...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Cell Line
- Cell Transformation, Neoplastic
- Enzyme Activation
- Fibroblasts
- Genes, ras
- Genes, src
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Peptide Mapping
- Phosphorylation
- Protein Serine-Threonine Kinases