Article
CYP2C19 genetic polymorphism in Thai, Burmese and Karen populations.
Drug metabolism and pharmacokinetics - 1 Aug 2006
Tassaneeyakul Wichittra, Mahatthanatrakul Werawath, Niwatananun Kanokporn, Na-Bangchang Kesara, Tawalee Arporn, Krikreangsak Nathawut, Cykleng Utaiwan, Tassaneeyakul Wongwiwat
Abstract excerpt
The genetic polymorphism of CYP2C19 was examined in three Southeast Asian populations. This study was conducted in 774 Thais, 127 Burmeses and 131 Karens. Genomic DNA was extracted from leucocytes and analyzed by the PCR-RFLP technique. Genotype analysis revealed that the allele frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 in the Thais were 0.68, 0.29 and 0.03, respectively, and those of the Burmese...
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