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Article

Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation.

Experimental cell research - 10 Jun 2004

Danielsen Andrew J, Christensen Trace A, Lovejoy Courtney A, Adelsman Margaret A, Connolly Denise C, Maihle Nita J

Abstract excerpt

The v-ErbB retroviral oncogene is a transduced, mutated copy of the avian EGF receptor gene, and its expression is sufficient to induce tumor formation in vivo. The structural alterations that release the oncogenic potential of the v-ErbB oncogene are similar to EGFR gene mutations described in human tumors. Thus, the study of v-ErbB tumor biology offers a useful model through which we can gain insight into the...

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Source

Identifiers

PMID: 15149858
DOI: 10.1016/j.yexcr.2004.01.023

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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