Article
Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation.
Experimental cell research - 10 Jun 2004
Danielsen Andrew J, Christensen Trace A, Lovejoy Courtney A, Adelsman Margaret A, Connolly Denise C, Maihle Nita J
Abstract excerpt
The v-ErbB retroviral oncogene is a transduced, mutated copy of the avian EGF receptor gene, and its expression is sufficient to induce tumor formation in vivo. The structural alterations that release the oncogenic potential of the v-ErbB oncogene are similar to EGFR gene mutations described in human tumors. Thus, the study of v-ErbB tumor biology offers a useful model through which we can gain insight into the...
Topics
- Animals
- Animals, Newborn
- Cell Line
- Cell Membrane
- Cell Transformation, Neoplastic
- Chick Embryo
- Chickens
- Fibroblasts
- Ligands
- Mutagenesis, Site-Directed
- Mutation
- Neoplasms
- Oncogene Proteins v-erbB
- Protein Transport
- Transformation, Genetic