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Article

Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.

Oncogene - 2 Oct 2003

Boerner Julie L, Danielsen Andrew J, Lovejoy Courtney A, Wang Ze, Juneja Subhash C, Faupel-Badger Jessica M, Darce Jaime R, Maihle Nita J

Abstract excerpt

Mutations within members of the EGF/ErbB receptor family frequently release the oncogenic potential of these receptors, resulting in the activation of downstream signaling events independent of ligand regulatory constraints. We previously have demonstrated that the signal transduction events originating from S3-v-ErbB, a ligand-independent, oncogenic EGF receptor mutant, are qualitatively distinct from the...

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PMID: 14555981
DOI: 10.1038/sj.onc.1206830

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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