Article
Activating ERBB4 mutations in non-small cell lung cancer.
Oncogene - 10 Mar 2016
Kurppa K J, Denessiouk K, Johnson M S, Elenius K
Abstract excerpt
Recent efforts to comprehensively characterize the mutational landscape of non-small cell lung cancer have identified frequent mutations in the receptor tyrosine kinase ERBB4. However, the significance of mutated ERBB4 in non-small cell lung cancer remains elusive. Here, we have functionally characterized nine ERBB4 mutations previously identified in lung adenocarcinoma. Four out of the nine mutations, Y285C,...
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