Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

doi:10.1073/pnas.1203201109

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Article

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

Proceedings of the National Academy of Sciences of the United States of America - 4 Sept 2012

Greulich Heidi, Kaplan Bethany, Mertins Philipp, Chen Tzu-Hsiu, Tanaka Kumiko E, Yun Cai-Hong, Zhang Xiaohong, Lee Se-Hoon, Cho Jeonghee, Ambrogio Lauren, Liao Rachel, Imielinski Marcin, Banerji Shantanu, Berger Alice H, Lawrence Michael S, Zhang Jinghui, Pho Nam H, Walker Sarah R, Winckler Wendy, Getz Gad, Frank David, Hahn William C, Eck Michael J, Mani D R, Jaffe Jacob D, Carr Steven A, Wong Kwok-Kin, Meyerson Matthew

Abstract excerpt

We assessed somatic alleles of six receptor tyrosine kinase genes mutated in lung adenocarcinoma for oncogenic activity. Five of these genes failed to score in transformation assays; however, novel recurring extracellular domain mutations of the receptor tyrosine kinase gene ERBB2 were potently oncogenic. These ERBB2 extracellular domain mutants were activated by two distinct mechanisms, characterized by elevated...

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PMID: 22908275
DOI: 10.1073/pnas.1203201109
PMCID: PMC3437859

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ERBB2

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