Androgen-independent growth of LNCaP prostate cancer cells is mediated by gain-of-function mutant p53.

Abstract excerpt

Mutations of p53 are common in hormone-refractory prostate cancer (CaP), suggesting the possibility that these mutations may be involved in the progression of CaP to androgen-independent (AI) growth. However, at present no direct evidence has been presented linking p53 mutations with AI growth of CaP. We established five stably transfected LNCaP cell lines: four containing gain-of-function (GOF) mutant p53...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Androgens
• Share to Genes, p53
• Share to Neoplasms, Hormone-Dependent