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Article

The DU145 human prostate carcinoma cell line harbors a temperature-sensitive allele of p53.

The Prostate - 15 Sept 2006

Bajgelman Marcio C, Strauss Bryan E

Abstract excerpt

BACKGROUND: Some nuances of mutant and wild-type p53 activity have been uncovered utilizing temperature sensitive (TS) alleles. However, few human tumor derived cell lines possess a TS p53 mutant. METHODS: The cell lines DU145 (heterozygous p53, P223L, and V274F) and PC3 (p53-null, where exogenous P223L and V274F were introduced individually or in combination) were examined for TS p53 activity as revealed by...

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Identifiers

PMID: 16741917
DOI: 10.1002/pros.20462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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