Article
Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells.
The Prostate - 1 Dec 2005
Tepper Clifford G, Gregg Jeffrey P, Shi Xu-Bao, Vinall Ruth L, Baron Colin A, Ryan Philip E, Desprez Pierre-Yves, Kung Hsing-Jien, deVere White Ralph W
Abstract excerpt
BACKGROUND: Tumor suppressor p53 mutations are associated with the transition of prostate cancer to metastatic, hormone-refractory disease and stable expression of p53 gain-of-function (p53GOF) alleles support growth of LNCaP in androgen-depleted medium. In this study, we performed gene expression profiling of four LNCaP-p53GOF sublines to test the hypothesis that different p53GOF mutants mediated androgen...
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