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Article

Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.

Molecular cancer research : MCR - 1 May 2010

Jordan Jennifer J, Inga Alberto, Conway Kathleen, Edmiston Sharon, Carey Lisa A, Wu Lin, Resnick Michael A

Abstract excerpt

Mutations of the sequence-specific master regulator p53 that alter transactivation function from promoter response elements (RE) could result in changes in the strength of gene activation or spectra of genes regulated. Such mutations in this tumor suppressor might lead to dramatic phenotypic changes and diversification of cell responses to stress. We have determined "functional fingerprints" of sporadic breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20407015
DOI: 10.1158/1541-7786.MCR-09-0442
PMCID: PMC2873663

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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