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Article

Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2007

Monti Paola, Ciribilli Yari, Jordan Jennifer, Menichini Paola, Umbach David M, Resnick Michael A, Luzzatto Lucio, Inga Alberto, Fronza Gilberto

Abstract excerpt

PURPOSE: The TP53 tumor suppressor gene encodes a sequence-specific transcription factor that is able to transactivate several sets of genes, the promoters of which include appropriate response elements. Although human cancers frequently contain mutated p53, the alleles as well as the clinical expression are often heterogeneous. Germ line mutations of TP53 result in cancer proneness syndromes known as...

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Identifiers

PMID: 17606709
DOI: 10.1158/1078-0432.CCR-06-2545
PMCID: PMC2128783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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