Article
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes.
Oncogene - 1 Jan 2022
McCann Jennifer J, Vasilevskaya Irina A, McNair Christopher, Gallagher Peter, Neupane Neermala Poudel, de Leeuw Renée, Shafi Ayesha A, Dylgjeri Emanuela, Mandigo Amy C, Schiewer Matthew J, Knudsen Karen E
Abstract excerpt
The tumor suppressor gene TP53 is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Specifically, missense mutations in TP53 are selectively enriched in PCa, and cluster to particular "hot spots" in the p53 DNA binding domain with mutation at the R273 residue occurring most frequently. While this residue is similarly mutated to R273C-p53 or R273H-p53 in all cancer types...
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