The genome of Plasmodium falciparum encodes an active delta-aminolevulinic acid dehydratase.

doi:10.1007/s00294-002-0273-3

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Article

The genome of Plasmodium falciparum encodes an active delta-aminolevulinic acid dehydratase.

Current genetics - 1 Mar 2002

Sato Shigeharu, Wilson R J M

Abstract excerpt

The enzyme delta-aminolevulinic acid dehydratase (ALAD) catalyses the second reaction in the heme biosynthetic pathway. It has been suggested previously that the malaria parasite Plasmodium falciparum imports this enzyme from the host cell for de novo heme biosynthesis. However, the parasite's genome encodes an orthologue for ALAD. Here we report molecular cloning of a complete cDNA for the parasite's intrinsic...

Topics

Allosteric Site
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Escherichia coli
Genetic Complementation Test
Molecular Sequence Data
Mutation
Phylogeny
Plants
Plasmodium falciparum
Porphobilinogen Synthase
Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 11919678
DOI: 10.1007/s00294-002-0273-3

Genes

ALAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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