Article

The heme precursor 5-aminolevulinic acid triggers the shutdown of the HemKR signalling system in <i>Leptospira</i>

2023-10-19

Abstract excerpt

<h4>SUMMARY</h4> Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant. Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate adaptive responses. HemKR is a TCS involved in the control of heme metabolism in Leptospira spirochetes. Howeve...

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Literature Corpus work: b7483f2e-64e4-50b6-9544-7cba285eb80d
DOI: 10.1101/2023.10.19.563136

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