Disruption of Plasmodium falciparum histidine-rich protein 2 may affect haem metabolism in the blood stage

Abstract excerpt

Abstract Background Haem is a key metabolic factor in the life cycle of the malaria parasite. In the blood stage, the parasite acquires host haemoglobin to generate amino acids for protein synthesis and the by-product haem for metabolic use. The malaria parasite can also synthesize haem de novo on its own. Plasmodium falciparum -specific histidine-rich protein 2 ( Pf HRP2) has a haem-binding site to mediate the...

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