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Article

Expression and functional analysis of the anaplastic lymphoma kinase (<i>ALK</i>) gene in tumor cell lines

29 May 2002

Abstract excerpt

The initial identification of the ALK gene, expressed as C-terminal part of the transforming fusion protein NPM-ALK in the t(2;5)(p23;q35) lymphoma-associated chromosomal translocation, revealed a novel receptor tyrosine kinase (RTK). In order to expand the knowledge on ALK expression in the human system, we examined a panel of human cell lines for ALK expression and found that transcription is completely...

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PMID: 12115586
DOI: 10.1002/ijc.10435

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