Determinants for transformation induced by the Axl receptor tyrosine kinase.

doi:10.1038/sj.onc.1201865

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Article

Determinants for transformation induced by the Axl receptor tyrosine kinase.

Oncogene - 18 Jun 1998

Burchert A, Attar E C, McCloskey P, Fridell Y W, Liu E T

Abstract excerpt

The Axl receptor tyrosine kinase is a transforming oncogene in NIH3T3 cells. In order to define structural requirements of the Axl receptor necessary for transformation we passaged recombinant retroviruses carrying the axl cDNA in NIH3T3 cells, generating randomly mutated axl variants. Using this...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Cell Transformation, Neoplastic
Mice
Molecular Sequence Data
Mutation
Oncogene Proteins
Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
Axl Receptor Tyrosine Kinase

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