Article
Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.
The American journal of pathology - 1 Apr 2002
Hernández Luis, Beà Sílvia, Bellosillo Beatriz, Pinyol Magda, Falini Brunangelo, Carbone Antonino, Ott German, Rosenwald Andreas, Fernández Alberto, Pulford Karen, Mason David, Morris Stephan W, Santos Eugenio, Campo Elias
Abstract excerpt
Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene at 2p23 that result in the expression of novel chimeric ALK proteins with transforming properties. In most of these tumors, the t(2;5)(p23;q35) generates the NPM-ALK fus...
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