Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALK-activating homologous mutations in LTK induce cellular transformation.

PloS one - 1 Jan 2012

Roll J Devon, Reuther Gary W

Abstract excerpt

Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase reported to be overexpressed in human leukemia. Though much regarding the function of LTK remains unknown, it shares a high degree of similarity with anaplastic lymphoma kinase (ALK), which is found mutated in human cancer. In order to determine if LTK has transforming potential, we created two LTK mutants, F568L and R669Q, that correspond to two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaplastic Lymphoma Kinase
Share to Cell Transformation, Neoplastic
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Mutation

Share to Phosphorylation

Share to Receptor Protein-Tyrosine Kinases

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 22347506
DOI: 10.1371/journal.pone.0031733
PMCID: PMC3276580

Genes

LTK
ALK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALK-activating homologous mutations in LTK induce cellular transformation.PMID 22347506Read ↗

Expression of the adaptor protein Lnk in leukemia cells.Semantic proximity Read ↗

ALK Fusion Partners Impact Response to ALK Inhibition: Differential Effects on Sensitivity, Cellular Phenotypes, and Biochemical Properties.Semantic proximity Read ↗

Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.Semantic proximity Read ↗

An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway.Semantic proximity Read ↗

New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases.Semantic proximity Read ↗

Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

KLF8 transcription factor participates in oncogenic transformation.Semantic proximity Read ↗

Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases.Semantic proximity Read ↗

An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex.Semantic proximity Read ↗

Determinants for transformation induced by the Axl receptor tyrosine kinase.Semantic proximity Read ↗

Generation and characterization of transforming variants of the lck tyrosine protein kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.