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Article

An in vivo selection system for homing endonuclease activity.

Nucleic acids research - 1 Apr 2002

Gruen Mathias, Chang Kathy, Serbanescu Irina, Liu David R

Abstract excerpt

Homing endonucleases are enzymes that catalyze the highly sequence-specific cleavage of DNA. We have developed an in vivo selection in Escherichia coli that links cell survival with homing endonuclease-mediated DNA cleavage activity and sequence specificity. Using this selection, wild-type and mu...

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Identifiers

PMID: 11917035
DOI: 10.1093/nar/30.7.e29
PMCID: PMC101853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11917035-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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