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Article

Insertion of a reversible redox switch into a rare-cutting DNA endonuclease.

Biochemistry - 19 Feb 2002

Posey Karen L, Gimble Frederick S

Abstract excerpt

Target sites for homing endonucleases occur infrequently in complex genomes. As a consequence, these enzymes can be used in mammalian systems to introduce double-strand breaks at recognition sites inserted within defined loci to study DNA repair by homologous and nonhomologous recombination. Using homing endonucleases for gene targeting in vivo would be more feasible if temporal or spatial regulation of their...

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Identifiers

PMID: 11841209
DOI: 10.1021/bi015944v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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