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Generation of Infectious Hepatitis C Virus in Immortalized Human Hepatocytes

12 Apr 2006

Abstract excerpt

Progress in understanding hepatitis C virus (HCV) biology has remained a challenge due to the lack of an efficient cell culture system for virus growth. In this study, we examined HCV core protein-mediated immortalized human hepatocytes (IHH) for growth of HCV. In vitro-transcribed full-length RNA from HCV genotype 1a (clone H77) was introduced into IHH by electroporation. Reverse transcription-PCR of cellular...

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PMID: 16611923
DOI: 10.1128/jvi.80.9.4633-4639.2006

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