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Article

An <i>in vitro</i> model of hepatitis C virion production

8 Feb 2005

Abstract excerpt

The hepatitis C virus (HCV) is a major cause of liver disease worldwide. The understanding of the viral life cycle has been hampered by the lack of a satisfactory cell culture system. The development of the HCV replicon system has been a major advance, but the system does not produce virions. In this study, we constructed an infectious HCV genotype 1b cDNA between two ribozymes that are designed to generate the...

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PMID: 15701697
DOI: 10.1073/pnas.0409666102

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