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Article

Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

1 Jul 1998

Abstract excerpt

Investigation of the hepatitis C virus (HCV) life cycle and the evaluation of novel antiviral strategies are limited by the lack of an efficient cell culture system. Therefore, continuous human cell lines inducibly expressing the entire HCV open reading frame were generated with use of a tetracycline-regulated gene expression system. HCV transgenes were found to be chromosomally integrated in a head-to-tail...

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PMID: 9657112
DOI: 10.1002/hep.510280125

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