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Article

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.

Nature cell biology - 1 Apr 2002

Mailand Niels, Lukas Claudia, Kaiser Brett K, Jackson Peter K, Bartek Jiri, Lukas Jiri

Abstract excerpt

We show that human Cdc14A phosphatase interacts with interphase centrosomes, and that this interaction is independent of microtubules and Cdc14A phosphatase activity, but requires active nuclear export. Disrupting the nuclear export signal (NES) led to Cdc14A being localized in nucleoli, which in unperturbed cells selectively contain Cdc14B (ref. 1). Conditional overproduction of Cdc14A, but not its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11901424
DOI: 10.1038/ncb777

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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