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Article

Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.

Molecular and cellular biology - 1 Feb 2007

Bloom Joanna, Cross Frederick R

Abstract excerpt

The phosphatase Cdc14 is required for mitotic exit in budding yeast. Cdc14 promotes Cdk1 inactivation by targeting proteins that, when dephosphorylated, trigger degradation of mitotic cyclins and accumulation of the Cdk1 inhibitor, Sic1. Cdc14 is sequestered in the nucleolus during most of the cell cycle but is released into the nucleus and cytoplasm during anaphase. When Cdc14 is not properly sequestered in the...

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Identifiers

PMID: 17116692
DOI: 10.1128/MCB.01069-06
PMCID: PMC1800703

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