Article
The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.
Molecular cell - 1 Dec 1998
Visintin R, Craig K, Hwang E S, Prinz S, Tyers M, Amon A
Abstract excerpt
Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity. Cdc14 dephosphorylates Sic1, a Cdk inhibitor, and Swi5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of...
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