Article
The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.
Molecular cell - 1 Dec 1998
Visintin R, Craig K, Hwang E S, Prinz S, Tyers M, Amon A
Abstract excerpt
Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity. Cdc14 dephosphorylates Sic1, a Cdk inhibitor, and Swi5, a tra...
Topics
- Anaphase-Promoting Complex-Cyclosome
- Cdh1 Proteins
- Cell Cycle Proteins
- Cyclin B
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cyclin-Dependent Kinases
- Cyclins
- DNA Replication
- DNA-Binding Proteins
- Fungal Proteins
- GTP-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Ligases
- Mitosis
- Mutation
- Phosphoprotein Phosphatases
- Phosphorylation