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Article

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

Scientific reports - 1 Jan 2011

Guillamot María, Manchado Eusebio, Chiesa Massimo, Gómez-López Gonzalo, Pisano David G, Sacristán María P, Malumbres Marcos

Abstract excerpt

Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack...

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Share to Gene Expression Regulation, Enzymologic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dual-Specificity Phosphatases

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Identifiers

PMID: 22355704
DOI: 10.1038/srep00189
PMCID: PMC3240995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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