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Article

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

Scientific reports - 1 Jan 2011

Guillamot María, Manchado Eusebio, Chiesa Massimo, Gómez-López Gonzalo, Pisano David G, Sacristán María P, Malumbres Marcos

Abstract excerpt

Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosph...

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Share to Gene Expression Regulation, Enzymologic
Share to Cell Cycle
Share to Dual-Specificity Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Source

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Identifiers

PMID: 22355704
DOI: 10.1038/srep00189
PMCID: PMC3240995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22355704-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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