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Article

BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.

Oncogene - 6 Aug 2009

Izumi H, Matsumoto Y, Ikeuchi T, Saya H, Kajii T, Matsuura S

Abstract excerpt

BubR1 is a critical component of the mitotic checkpoint that delays the onset of anaphase until all chromosomes have established bipolar attachment to the microtubules. We previously reported that mutations of the BUB1B gene (encoding BubR1) caused premature chromatid separation (PCS) syndrome, a condition characterized by constitutional aneuploidy and a high risk of childhood cancer. We here report that the...

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Identifiers

PMID: 19503101
DOI: 10.1038/onc.2009.141

Genes

BUB1B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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