Article
BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
Oncogene - 6 Aug 2009
Izumi H, Matsumoto Y, Ikeuchi T, Saya H, Kajii T, Matsuura S
Abstract excerpt
BubR1 is a critical component of the mitotic checkpoint that delays the onset of anaphase until all chromosomes have established bipolar attachment to the microtubules. We previously reported that mutations of the BUB1B gene (encoding BubR1) caused premature chromatid separation (PCS) syndrome, a condition characterized by constitutional aneuploidy and a high risk of childhood cancer. We here report that the...
Topics
- Abnormalities, Multiple
- Cell Cycle Proteins
- Cell Line
- Centrosome
- Chromatids
- Green Fluorescent Proteins
- HCT116 Cells
- HeLa Cells
- Humans
- Immunoblotting
- Immunoprecipitation