Article
Cooperation of Hoxa5 and Pax1 genes during formation of the pectoral girdle.
Developmental biology - 1 Apr 2002
Aubin Josée, Lemieux Margot, Moreau Julie, Lapointe Jérôme, Jeannotte Lucie
Abstract excerpt
Hox and Pax transcription factors are master regulators of skeletal and organ morphogenesis. Some skeletal malformations encountered in Hoxa5 mutants are shared by the undulated (un) mice, which bear a point mutation in the Pax1 gene. To investigate whether Hoxa5 and Pax1 act in common pathways during skeletal development, we analyzed Hoxa5;un compound mutants. Our genetic studies show that Hoxa5 and Pax1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
