Article
Hox genes and regional patterning of the vertebrate body plan.
Developmental biology - 1 Aug 2010
Mallo Moises, Wellik Deneen M, Deschamps Jacqueline
Abstract excerpt
Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatio-temporally controlled...
Topics
- Animals
- Body Patterning
- Body Size
- Developmental Biology
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Homeodomain Proteins
- Humans
- Mice
- Models, Biological