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Article

Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model

5 Aug 2020

Abstract excerpt

Abstract Vaccination with vaccinia virus (VACV) elicits heterotypic immunity to smallpox, monkeypox, and mousepox, the mechanistic basis for which is poorly understood. It is generally assumed that heterotypic immunity arises from the presentation of a wide array of VACV-derived, CD8+ T cell epitopes that share homology with other poxviruses. Herein this assumption was tested using a large panel of VACV-derived...

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PMID: 32759969
DOI: 10.1038/s41598-020-69897-w

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