Article
Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles.
Human immunology - 1 Apr 2003
Lacey Simon F, Villacres Maria C, La Rosa Corinna, Wang Zhongde, Longmate Jeff, Martinez Joybelle, Brewer John C, Mekhoubad Shahram, Maas Rebecca, Leedom John M, Forman Stephen J, Zaia John A, Diamond Don J
Abstract excerpt
CD8(+) T-cell responses to three human cytomegalovirus (CMV) pp65 epitopes were studied in panels of healthy seropositive HLA-A*02/HLA-B*07 individuals, and HLA-A*02 donors mismatched for HLA-B*07. The majority of the latter had significant responses to a HLA-A*02-restricted epitope within the CMV pp65 antigen. By contrast, the strongest responses to CMV in the first group were to HLA-B*07-restricted epitopes....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.