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Article

Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide.

1 Sept 1993

Abstract excerpt

An immunological basis has been postulated for the strong association between at least five subtypes of the HLA-B27 allele (B27.01, .02, .04, .05, and .06) and ankylosing spondylitis, namely that cytotoxic T lymphocyte (CTL) responses are induced against an "arthritogenic" peptide that these different subtypes can all present. This requires a degree of overlap between the peptide binding repertoires of different...

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Identifiers

PMID: 7688791
DOI: 10.1084/jem.178.3.879

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