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Article

Activation of the Wnt/β-catenin pathway is common in wilms tumor, but rarely through β-catenin mutation and APC promoter methylation.

Pediatric surgery international - 1 Dec 2016

Schweigert Amei, Fischer Carmen, Mayr Doris, von Schweinitz Dietrich, Kappler Roland, Hubertus Jochen

Abstract excerpt

PURPOSE: The Wnt/β-catenin pathway is known to be crucial for the regulation of embryogenesis and cell differentiation, and its constitutive activation is associated with a wide range of malignancies. There are two major principles for an activated Wnt/β-catenin pathway. The first is caused by the failure of the destruction complex, mainly due to the decreased expression of the tumor suppressor gene adenomatous...

Read the complete abstract on PubMed

Topics

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Share to beta Catenin
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Infant

Share to Promoter Regions, Genetic

Share to Signal Transduction

Share to Wilms Tumor

Share to Wnt Proteins

Source

Identifiers

PMID: 27679509
DOI: 10.1007/s00383-016-3970-6

Genes

APC
AXIN2
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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