Article
AXIN1 mutations but not deletions in cerebellar medulloblastomas.
Oncogene - 30 Jan 2003
Baeza Nathalie, Masuoka Jun, Kleihues Paul, Ohgaki Hiroko
Abstract excerpt
Medulloblastoma is a malignant, invasive embryonal tumour of the cerebellum which manifests preferentially in children. A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrome), and APC and beta-catenin point mutations occur in up to 10% of sporadic cases, indicating the involvement of the Wnt pathway in the development of medulloblastoma. In 39 sporadic cerebellar...
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