Article
Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review.
Neuro endocrinology letters - 1 Jul 2017
Hlouskova Alena, Bielik Peter, Bonczek Ondrej, Balcar Vladimir J, Šerý Omar
Abstract excerpt
AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were...
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