Article
A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.
PloS one - 1 Jan 2014
Booth Antonia E G, Tarafder Abul K, Hume Alistair N, Recchi Chiara, Seabra Miguel C
Abstract excerpt
The mechanism(s) by which Rab GTPases are specifically recruited to distinct intracellular membranes remains elusive. Here we used Rab27a localisation onto melanosomes as a model to investigate Rab targeting. We identified the α1 subunit of Na+,K+-ATPase (ATP1a1) as a novel Rab27a interacting protein in melanocytes and showed that this interaction is direct with the intracellular M4M5 loop of ATP1a1 and...
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