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Article

The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes.

Molecular and cellular biology - 1 Aug 2003

Kuroda Taruho S, Ariga Hiroyoshi, Fukuda Mitsunori

Abstract excerpt

Melanosomes containing melanin pigments are transported from the cell body of melanocytes to the tips of their dendrites by a combination of microtubule- and actin-dependent machinery. Three proteins, Rab27A, myosin Va, and Slac2-a/melanophilin (a linker protein between Rab27A and myosin Va), are known to be essential for proper actin-based melanosome transport in melanocytes. Although Slac2-a directly interacts...

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Identifiers

PMID: 12861011
DOI: 10.1128/MCB.23.15.5245-5255.2003
PMCID: PMC165717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes.PMID 12861011Read ↗

Functional analysis of Slac2-c/MyRIP as a linker protein between melanosomes and myosin VIIa.Semantic proximity Read ↗

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.Semantic proximity Read ↗

Missense mutations in the globular tail of myosin-Va indilutemice partially impair binding of Slac2-a/melanophilinSemantic proximity Read ↗

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