Article
A tissue-specific exon of myosin Va is responsible for selective cargo binding in melanocytes.
Cell motility and the cytoskeleton - 1 Oct 2002
Au Josephine Sui-Yan, Huang Jian-Dong
Abstract excerpt
Class V myosins are molecular motors used for intracellular transportation and organelle tethering. The mouse Myosin Va (MyoVa) is encoded by the dilute locus, which is alternatively spliced to generate several tissue specific isoforms. The tail of MyoVa is the putative cargo-binding domain. To determine the functions of different isoforms of MyoVa and the minimal cargo-binding region, we tagged various isoforms...
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