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Article

Protein kinase A deficiency causes axially localized neural tube defects in mice.

The Journal of biological chemistry - 31 May 2002

Huang Yongzhao, Roelink Henk, McKnight G Stanley

Abstract excerpt

We have studied the function of protein kinase A (PKA) during embryonic development using a PKA-deficient mouse that retains only one functional catalytic subunit allele, either Calpha or Cbeta, of PKA. The reduced PKA activity results in neural tube defects that are specifically localized posterior to the forelimb buds and lead to spina bifida. The affected neural tube has closed appropriately but exhibits an...

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Identifiers

PMID: 11886853
DOI: 10.1074/jbc.M111412200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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