Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenic inhibitors identify two roles for protein kinase A in Drosophila development.

Genetics - 1 May 1999

Kiger J A, Eklund J L, Younger S H, O'Kane C J

Abstract excerpt

We have initiated an analysis of protein kinase A (PKA) in Drosophila using transgenic techniques to modulate PKA activity in specific tissues during development. We have constructed GAL4/UAS-regulated transgenes in active and mutant forms that encode PKAc, the catalytic subunit of PKA, and PKI(1-31), a competitive inhibitor of PKAc. We present evidence that the wild-type transgenes are active and summarize the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Cyclic AMP-Dependent Protein Kinases
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insect Proteins

Share to Microscopy, Phase-Contrast

Share to Pyruvate Kinase

Share to Transgenes

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 10224260
DOI: 10.1093/genetics/152.1.281
PMCID: PMC1460600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenic inhibitors identify two roles for protein kinase A in Drosophila development.PMID 10224260Read ↗

Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other TumorsSemantic proximity Read ↗

Type II cAMP-dependent protein kinase-deficient Drosophila are viable but show developmental, circadian, and drug response phenotypes.Semantic proximity Read ↗

Mouse models of altered protein kinase A signalingSemantic proximity Read ↗

Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo.Semantic proximity Read ↗

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.Semantic proximity Read ↗

Protein kinase A deficiency causes axially localized neural tube defects in mice.Semantic proximity Read ↗

Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.Semantic proximity Read ↗

Cell-type specific expression of a dominant negative PKA mutation in mice.Semantic proximity Read ↗

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.Semantic proximity Read ↗

Localization and functions of protein kinase A during Drosophila oogenesis.Semantic proximity Read ↗

Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins.Semantic proximity Read ↗

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.