Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development.

doi:10.1016/0092-8674(95)90509-x

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Article

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development.

Cell - 24 Feb 1995

Li W, Ohlmeyer J T, Lane M E, Kalderon D

Abstract excerpt

Reduced protein kinase A (PKA) activity in anterior imaginal disc cells leads to cell-autonomous induction of decapentaplegic (dpp), wingless (wg), and patched (ptc) transcription that is independent of hedgehog (hh) gene activity. The resulting nonautonomous adult wing and leg pattern duplicatio...

Topics

Animals
Congenital Abnormalities
Cyclic AMP-Dependent Protein Kinases
Drosophila
Drosophila Proteins
Female
Gene Expression Regulation
Hedgehog Proteins
Insect Hormones
Larva
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Models, Genetic

Mutation

Protein Biosynthesis

Proteins

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 7867063
DOI: 10.1016/0092-8674(95)90509-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7867063-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development.PMID 7867063Read ↗

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