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Article

Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo.

The Journal of biological chemistry - 26 Jul 2002

Amieux Paul S, Howe Douglas G, Knickerbocker Heidi, Lee David C, Su Thomas, Laszlo George S, Idzerda Rejean L, McKnight G Stanley

Abstract excerpt

A targeted disruption of the RIalpha isoform of protein kinase A (PKA) was created by using homologous recombination in embryonic stem cells. Unlike the other regulatory and catalytic subunits of PKA, RIalpha is the only isoform that is essential for early embryonic development. RIalpha homozygous mutant embryos fail to develop a functional heart tube at E8.5 and are resorbed at approximately E10.5. Mutant...

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Identifiers

PMID: 12004056
DOI: 10.1074/jbc.M200302200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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