Article
Local activation of protein kinase A inhibits morphogenetic movements during Xenopus gastrulation.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2003
Song Byung-Ho, Choi Sun-Cheol, Han Jin-Kwan
Abstract excerpt
cAMP-dependent protein kinase (PKA) has various biological roles in many organisms. However, little is known about its role in the developmental processes of vertebrates. In this study, we describe the functional analysis of PKA during gastrulation movements in Xenopus laevis. Overexpression of constitutively active PKA (cPKA) in the dorsal equatorial region of the embryo affects morphogenetic movement during...
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