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Article

Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2005

Zhu Huiping, Lu Wei, Laurent Cecile, Shaw Gary M, Lammer Edward J, Finnell Richard H

Abstract excerpt

BACKGROUND: PRKACA and PRKACB are genes encoding the cAMP-dependent protein kinase A (PKA) catalytic subunits alpha and beta, respectively. PKA is known to be involved in embryonic development, as it down-regulates the Hedgehog (Hh) signaling pathway, which is critical to normal pattern formation and morphogenesis. The PKA-deficient mouse model, which has only a single catalytic subunit, provided intriguing...

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Identifiers

PMID: 16080189
DOI: 10.1002/bdra.20175
PMCID: PMC2970525

Genes

PRKACA
PRKACB
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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