Article
Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype.
International journal of cancer - 10 Jan 2004
Ibrahim El Chérif, Aractingi Sélim, Allory Yves, Borrini Francesco, Dupuy Alain, Duvillard Pierre, Carosella Edgardo D, Avril Marie Françoise, Paul Pascale
Abstract excerpt
Previous studies indicate that the nonclassical class I HLA-G antigen, whose physiologic expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung carcinoma, glioblastoma and ovarian carcinoma, where its inhibitory effect on cytotoxic effector cells function i...
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