Article
The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.
Molecular and cellular biology - 1 Apr 2002
Dickins Ross A, Frew Ian J, House Colin M, O'Bryan Moira K, Holloway Andrew J, Haviv Izhak, Traficante Nadia, de Kretser David M, Bowtell David D L
Abstract excerpt
The mammalian Siah genes encode highly conserved proteins containing a RING domain. As components of E3 ubiquitin ligase complexes, Siah proteins facilitate the ubiquitination and degradation of diverse protein partners including beta-catenin, N-CoR, and DCC. We used gene targeting in mice to analyze the function of Siah1a during mammalian development and reveal novel roles in growth, viability, and fertility....
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